Metabolic Information Engineering

Starting from essential issues such as the depletion of oil resources and the necessity to reduce carbon dioxide emissions in recent years, the society needs to convert synthesis of useful chemical materials from petroleum-derived chemical processes towards bioprocesses. Using the bacteria called "bacillus subtilis" as a host, we have set as objective the creation of a "generic high-efficiency bioprocess cell", capable to produce various useful chemical compounds. In addition, we aim to build up a process of conversion of the introduced raw material into the target compound, during the stationary phase when cell does not proliferate. Using informational techniques, by designing optimal metabolic pathways for the conversion of the raw material into the target compound and by metabolizing the cell substrates labeled with stable isotopes, we have been clarifying the intracellular enzymatic reaction rate and evaluating the actual metabolism of the cells.

• 2010 Ph.D. Keio University
• 2010 Project assistant professor, Graduate School of Media and Governance, Keio University
• 2011 Project Assistant Professor, Graduate School of Information Science and Technology, Osaka University